The novel virus Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread around the globe and poses a serious health, economic, and social threat. Defeating the virus calls for a comprehensive toolkit of detection solutions to complement PCR-based diagnostics – like ELISA-based antibody tests – and to uncover the role of biomarkers such as HMGB1, Neopterin, TNF-alpha, Vitamin D and Interleukin-6 (IL-6) that are discussed in the literature as relevant to infection and disease progression.
Always there for you and the thousands of researchers worldwide working around the clock to find answers, Tecan brings you streamlined and reliable detection solutions to get a handle on this virus.
Boosting the fight against COVID-19 with HMGB1, Neopterin, TNF-alpha, IL-6 and
Vitamin D.
SARS-COV-2
Detect infection and immune response.
Detect IgA, IgG and IgM to understand the epidemiological profile of SARS-CoV-2. The different antibodies complement PCR-based diagnostics and serve as a public health tool.
HMGB1
Gain insights into COVID-19 etiology. HMGB1 plays a crucial role in the pathogenesis of COVID-19. As a key mediator of the immune system, HMGB1 appears to be involved in SARS-CoV-2 replication and in regulating the inflammatory response in COVID-19. [REF: Andersson et al, 2020]
Neopterin
Spot an ongoing immune reaction.
Neopterin can be detected before any observable signs of infection, and thus, may be a tool for early detection of COVID-19. [REF: Robertson et al, 2020; Ozger et al, 2020]
TNF-alpha (RUO)
Characterize the progression of infections.
TNF-α is released in the presence of viral infections, endotoxins, bacterial liopopolysaccharides or other foreign elements, as well as in response to tissue injury or DNA damage.
Vitamin D
Identify potential risk of infection.
Vitamin D deficiency has been noted as a risk factor in COVID-19 due to its relation to the renin/angiotensin system, which regulates blood pressure.
IL-6 (RUO)
Profile the body’s defense mechanism.
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates immune responses and may be a valuable parameter in understanding that response to COVID-19. [REF: Chen et al., 2020; Diao et al. 2020; Conti et al., 2020]
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