Faster process development insights using Antha’s flexible, traceable, integrated end-to-end purification workflow
Dr. Arne Vandenbroucke - Synthace Ltd.
In collaboration with Tecan, Synthace Ltd has developed an integrated, end-to-end protocol on using their software Antha that cuts down time needed to plan, track, execute, analyse and share miniaturized purification workflows, thereby facilitating high throughput process development (HTPD) and process analytical technology (PAT).
In this presentation, we firstly demonstrate the flexible design of a purification workflow, and the data alignment capabilities, yielding a 5-fold decrease in time to visualisation. Next, we show how A280 absorption data can easily be augmented with external data, for example from a LabChip® GXII electrophoresis system. Finally, we present how instructions for a 24-parameter, 6-resin DOE are effortlessly created, split across independent runs, and how data from these runs is effortlessly combined together.
Key focus areas:
High throughput purification, laboratory data management, Design of Experiments.
Dr Arne Vandenbroucke is the Product Lead for Miniaturised Purification and Senior Automation Engineer at Synthace Ltd. He leads the product strategy and development for Synthace’s partnership with Tecan to integrate the Antha software platform with Tecan’s Te-Chrom™ automated chromatography systems on Freedom EVO® and Fluent® platforms. Prior to joining Synthace, Dr Vandenbroucke developed liquid handling and molecular imaging systems, automated workflows, and data analysis pipelines at Labcyte Inc., Specific Diagnostics LLC, and Stanford University. He completed his PhD in Experimental Particle Physics at Ghent University.