General information about the biomarker HMGB1
Over the years, HMGB1 has increasingly attracted the attention of basic as well as clinical researchers, and has become one of the most intriguing molecules within the complete arsenal of proteins of the innate immune system.
HMGB1 is a nuclear protein that can bind and bend DNA, but it can also be released to the extracellular environment, where it exerts additional functions. Once released into the cytoplasm by immunocompetent cells, HMGB1 is involved in disease pathogenesis and inflammation (damage-associated molecular pattern, DAMP). HMGB1 is also associated with numerous pathologies,¹ including