Interrogate COVID-19 with Tecan’s HMGB1 Express ELISA

Designed to give you deeper insights into an individual’s immune response to any infection, including the SARS-CoV-2 virus.

General information about the biomarker HMGB1

Over the years, HMGB1 has increasingly attracted the attention of basic as well as clinical researchers, and has become one of the most intriguing molecules within the complete arsenal of proteins of the innate immune system.

HMGB1 is a nuclear protein that can bind and bend DNA, but it can also be released to the extracellular environment, where it exerts additional functions. Once released into the cytoplasm by immunocompetent cells, HMGB1 is involved in disease pathogenesis and inflammation (damage-associated molecular pattern, DAMP). HMGB1 is also associated with numerous pathologies,¹ including

  • Inflammatory diseases
  • Respiratory diseases
  • Autoimmune diseases
  • Sepsis
  • Cancer
  • Diabetes
  • Myocardial infarction and others
  • Inflammatory diseases
  • Respiratory diseases
  • Autoimmune diseases
  • Sepsis
  • Cancer
  • Diabetes
  • Myocardial infarction and others

Being a severe acute respiratory syndrome disease, COVID-19 might cause significant damage to the lungs and, if involved with comorbidities, lead to death. Openly-published statistics indicate that, despite being on ventilation, approximately 85 % of these patients still die. A recent review shows how HMGB1 might indicate the severity of SARS-CoV-2 associated inflammation in the lungs.²

 

Read more about the role of HMGB1 in the immune response to COVID-19:

Exploring the role of HMGB1 in the immune response to COVID-19

How to measure alarmin HMGB1 in SARS-CoV-2 immune response

High Quality ELISA for measuring HMGB1 in COVID-19 samples

¹ Kang R, et al. HMGB1 in health and disease. Mol Aspects Med, 2014, 40, 1-116.

² Andersson U, et al. Extracellular HMGB1: A therapeutic target in severe pulmonary inflammation including COVID-19? Mol Med, 2020, 26, 42. doi: 10.1186/s10020-020-00172-4

Our HMGB1 assays are used by scientists worldwide as the gold standard for HMGB1 evaluation and quantification

The HMGB1 Express ELISA (#30164033) is the successor of Tecan’s most referenced HMGB1 ELISA (#ST51011).

Benefits and specifications of the HMGB1 Express ELISA kit include

  • Reliability and reproducibility
  • Assay time of only 4 hours
  • Wide measuring range (0.89-80 ng/ml
  • Can be used manually or can be automated on open-format ELISA processors*
  • Can be used for preclinical and clinical studies
  • Provides quantitative determination of HMGB1 in human serum and plasma (EDTA, citrate)
  • Regulatory status EU: CE**
  • Reliability and reproducibility
  • Assay time of only 4 hours
  • Wide measuring range (0.89-80 ng/ml
  • Can be used manually or can be automated on open-format ELISA processors*
  • Can be used for preclinical and clinical studies
  • Provides quantitative determination of HMGB1 in human serum and plasma (EDTA, citrate)
  • Regulatory status EU: CE**

Get a detailed summary of the functions of HMGB1 with our dedicated “HMGB1 poster” or browse our product flyers to gain insights into researching HMGB1.

Download-Flyer-HMGB1-Interrogate-Covid-19_720x370

 

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* The combined use of assay, process script and instrument must be validated individually on site by each laboratory.

** HMGB1 express ELISA may not be available in your area. Please contact your local Tecan representative.

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