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Automated metabolic analysis in photodynamic tumor therapy
Photodynamic Therapy (PDT) is being increasingly recognized as having potential for the treatment of tumors, especially dermatological. But using conventional manual methods of recording the metabolic processes that occur as a result of adding the photosensitizer to target cells has major limitations.
For a start, monitoring response processes can take up to three days, which leads to night gaps that can introduce an element of error into capturing data. Also the number of parameters is limited by the fact that it’s only possible to work manually with 96-well plates.
Dr. Kristjan Plaetzer at the University of Salzburg, Austria set out to see whether there were benefits to automating the entire PDT process, from seeding cells to monitoring response processes. He used a Tecan Spark® 10M reader along with a standard plate wash. The results proved conclusively that automation increases accuracy, maximizes the number of parameters that can be tested in a single experiment and minimizes costs by saving time and money.
Dr Plaetzer’s presentation of his impressive findings is essential viewing if you’re the head of an academic laboratory, interested in cancer therapies or long-term research on metabolic processes. But it’s also required viewing for anyone who is researching into the benefits of automation.
Miniaturization impowered - discovering the remarkable benefits of the Tecan D300e
This presentation by Dr. Manuel Bauer - Product Manager, Liquid Handling and Robotics at Tecan - is an eye-opening introduction to the sheer power of the Tecan D300e Digital Dispenser. Without giving too much away, all you need to do is add your liquid and the dispenser does the rest.
Leveraging tried and tested HP thermal inkjet technology, the Tecan D300e offers picoliter to microliter noncontact dispensing of liquids directly to your assay plate. The Tecan D300e has the potential to radically transform the way enzyme profiles, synergy experiments and dose-response curves are performed. With enormous benefits for industries as diverse as pharmaceutical drug discovery, proteomics, genomics and cosmetics.
As Manuel explains, savings in set-up time, labor, errors, compounds, and hazardous chemical waste are remarkable. Just to give a single example, one customer reported that their set-up time was cut from an entire afternoon to less than 15 minutes.
The Tecan D300e’s disposable Dispenseheads minimize dead volumes and virtually eliminate the risk of cross-contamination. You’re also able to randomize plate layout to eliminate plate effects. Other features include the ability to set up drug-to-drug titrations or enzyme profiles in minutes.
If your work involves performing enzyme profiles, synergy experiments and dose-response curves, you need to watch Manuel’s presentation.
“Self aware” automation
What have I done? What am I doing? What am I going to do next? What’s going on around me? Knowing the answer to these questions is being self aware.
What happens when the robots in your lab become self aware? Hal Wehrenberg, Product Manager Software at Tecan answers this in his thought-provoking, entertaining presentation, filmed at SLAS 2016. Hal shows how Tecan’s Fluent® self aware automation can maximize productivity, provide accurate results you can trust, simplify your life and help you react with confidence to ever-changing conditions. Fluent will even help make sure a computer crash isn’t the end of the world. As Hal says “Fluent always knows what’s going on.”
If you want to know what’s going on with Fluent and how it can radically change the way you view robotics at work, watch Hal’s excellent presentation now.
The path from testing to a successful project
Wolfgang Jörg is the head of the Electronics/Lab Automation at Boehringer Ingelheim (BI). BI has been working with us ever since it purchased its first Tecan 5000 back in 1996. The company has completed over 80 automation projects using Tecan for pipetting, along with a competitor.
Since 2011, BI has been investing in ever larger automation systems. In 2015 a colleague of Wolfgang’s asked him if he could recommend an automation system that could be used in a project named Compounds in Plate Dissolution Station (CIPDIS). Wolfgang decided he’d like to test the Fluent® 780.
Tecan agreed to provide the system for free with the agreement that if it met Wolfgang’s expectations, the Fluent 780 would be purchased by BI. Wolfgang’s presentation, one of the most popular at our booth over the two days of SLAS 2016, describes in valuable detail how the CIPDIS project went. And how did the Fluent 780 perform? Watch Wolfgang’s presentation now and find out.
Validation of an automated method to remove ß-glucuroridase from hydrolyzed pain management urine samples
If your lab is offering LCMS based drugs-of-abuse testing services, this presentation by Rick Thomas, Chief Scientific Officer at Precision Diagnostics offers excellent insight into how you can reduce error and downtime and maximize efficiency.
Rick shows in considerable detail how the FreedomEVO® 200 platform enables his lab to process as many as 1600 samples for three assays during the course of an eight to ten-hour day.
As you’ll see, Rick knows Tecan’s products inside out and has a wealth of experience working with them in a challenging diagnostics environment. You couldn’t ask for a better person than Rick to demonstrate how Tecan’s automation solutions are key to keeping costs low and employee satisfaction high, while offering high quality diagnostic data.
And, if you’re based in the San Diego area, Rick ends his presentation with a really useful guide to who you should be talking to when it comes to really getting the most out of your Freedom EVO platform.
Catch and release screening center lands clients with D300
Since 2007, Oregon Translational Research and Development Institute (OTRADI) has operated Oregon’s only non-profit, proof-of-concept bioscience laboratories, with unique robotic equipment and scientific expertise found nowhere else in Oregon. OTRADI has used its expertise and research to generate more than $1 million of revenue to support scientific expansion and outreach.
For Dylan Nelson Automation Scientist at OTRADI, the D300 is the ultimate hands-on way to help clients discover and develop drugs. In this fact-filled presentation Dylan explains how the D300, the ‘scientists’ printer’, offers unbeatable benefits when it comes to doing more, faster, working independently, lowering risk caused by human error and saving money.
If you’re interested in finding out more about probably the most straightforward way to gain and provide hands-on experience of a semi-automated workflow, Dylan’s presentation is definitely the place to start.
Saving time with the Fluent® approach
Joe Zer is an Associate Scientist at Dart NeuroScience, working in a CMG lab which handles over 1000 compounds a week from different sources. Dart has been using the Fluent® 1080 since June 2015, mainly in the plating process and Joe works with a MultiChannel Arm™ (MCA) with 384 channels and two adapters.
In his entertaining and informative presentation Joe explains in seriously persuasive detail Dart’s journey to purchasing a Fluent when the company was “looking for something special” as he puts it. He goes on to show how the Fluent, with its flexibility, capacity and easily programmable software has tripled production in the lab and made the machine Dart’s “workhorse for the plating process”.
For very good reasons, as you’ll find out, Joe is a fan of Fluent – he describes it as “really really cool” – and his enthusiasm for the machine is absolutely contagious. As you’ll see.Watch the video >
The top 5 pitfalls of custom automation
Avinash Peddi of Tecan has been involved with lab automation for a number of years and, by his own estimation, has worked with several hundred customers on multiple projects. In this provocative but highly informative film, Avinash reveals the top 5 pitfalls when it comes to custom automation based on his own wealth of experience of projects which were unsuccessful.
Without revealing too much, Avinash’s top 5 pitfalls include failing to understand what the shift from manual to automated is all about, making too many unsupported assumptions and failing to future-proof. Along the way, Avinash goes into extremely valuable detail about what needs to happen if an organization wants to succeed by embracing automation.
If you’re considering automation and want to know what it really means, Avinash’s presentation is an eye-opener. And you’ll never look at a dishwasher in the same way again.
Simplifying cell assays with automated confluence determination
When it comes to drug development, the challenge is always to create as much in-vivo relevant data as possible. The more relevant in-vivo data you can gather, the lower the risk of the drug not passing a clinical trial.
But determining confluence is labor-intensive and prone to error and manual QC for cell-based assays is extremely time-consuming. At the same time, walk-away automation is also difficult to implement. So what’s the answer?
In this illuminating short presentation filmed at SLAS2016, Michael Fejtl, Market Manager Detection at Tecan, shows how our new Spark® 20M automates cell imaging, simplifies time consuming cell assays and provides confidence in what you’re measuring.
If you’re involved in data gathering for drug development, boosting the number of assays you do, simplifying the process and improving accuracy has to be a significant step forward. Watch Michael’s presentation now and find out more about what tomorrow could look like for your lab.
Accelerate drug discovery - Spark® 20M
Siegfried Sasshofer is responsible for the marketing of microplate readers and washers for Tecan. So he’s in an excellent position to speak about the outstanding benefits of the new Spark® 20M when it comes to accelerating the drug discovery process.
As Siegfried explains, the Spark® 20M has been developed as a response to the fact that the work of labs is getting more varied and demanding, whether we’re talking biochemical assays or more cell-based work.
Siegfried’s presentation clearly and simply sets out the benefits of the Spark® 20M for optimizing assays, standardizing cell-based assays and overcoming the challenges of multiplex. Among the features Siegfried showcases are a revolutionary new optical set-up that offers extra flexibility, industry-leading sensitivity and the Spark® 20M’s considerable advantages when it comes to walk-away automation.
But, as you’ll discover, there’s much more to the Spark® 20M. Including a unique feature which has to do with the first Nobel Prize winner for chemistry and a baby alligator. Here’s a clue: temperature defines destiny.
How do you reduce problems associated with smaller samples? Here’s our tip.
Like every industry, the Life Sciences is driving for more effective methods. One clear focus is towards the sampling of smaller volumes. From sample handling to molecular diagnostics, savings can be made through using less reagent per sample – as little as 10 or even 5 microliters.
Keep cool. There’s a better life ahead for your bioassay
Confident decisions in drug discovery builds on reliable results from bioassays. Maintaining a stable temperature is critical for consistency. Te-Cool™ now ensures that your live cell bioassays for enzymatic and kinetic studies are run to the highest standards. Tecan introduces the Spark® 20M microplate reader with Te-Cool. It’s the coolest idea for empowering your research and screening studies.
Solving the top four automation challenges of the discovery lab
Tecan Expert Simon Fogarty presents some of the automation challenges that Tecan regularly solves. If you think we can help you, please consider scheduling a consult with one of our Experts at SLAS2016, Booth #831.
Ramp up productivity in drug discovery
Eliminate hurdles in compound management and liquid handling
Screening demands massive automation of liquid handling and compound management that delivers robust data. Fluent®, our Laboratory Automation Solution, already delivers high capacity and speed with superior precision. New updates to Fluent now take productivity in drug discovery to an even higher level.
Breaking the resistance to anticancer drugs
Part 1 of 3: How a failed contraceptive led to targeted therapy success.
In 1996, Dr. Charles Sawyers at Memorial Sloan Kettering Cancer Center, USA, became involved in the initial testing of a drug for the treatment of chronic myeloid leukemia (CML). The drug, imatinib (later to be launched as Gleevec), could be taken once a day with few side effects and had a dramatic clinical result. Even patients in advanced stages of the disease, reliant on oxygen and with only a few weeks to live, became symptom-free almost immediately. The trouble was, those same patients quickly developed a resistance to the drug and suffered a relapse.
Breaking the resistance to anticancer drugs
Part 2 of 3: Chasing a moving target
The so-called ‘War against Cancer’ started with US President Richard Nixon’s National Cancer Act of 1971. It turned out to be many battles on many fronts as cancer was confirmed to be not one but a myriad of diseases. Not only that, but each cancer cell in a given patient has a different genetic make-up. It can differ in its response to treatment and also its ability to develop resistance.
Breaking the resistance to anticancer drugs
Part 3 of 3: Let’s make this personal
In the first part of this series, we introduced you to imatinib (Gleevec). This drug was originally launched in 2001 as a potent treatment for chronic myeloid leukemia (CML). It also proved to be effective against a number of other cancers.
Before the introduction of Gleevec, a diagnosis of CML was effectively a death sentence. The initial promise of spectacular results in treatment were, however, dampened somewhat by the development of resistance. But genetic research is now changing the rules.
Be confident in your data from automated live cell-based assays
Now it’s easy to keep an eye on your cells with the new Spark 10M, which includes imaging for normalizing signals, monitoring cell quality, and triggering actions.
Adam Steltzner: More than just a crazy rock and roll engineer
There are plenty of good reasons why you should catch Adam Steltzner’s keynote speech at SLAS 2016 or, if that’s out of the question, read his new book The Right Kind of Crazy: A True Story of Teamwork, Leadership and High Stakes Innovation.
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Dr. Gottesman: On the forefront of the fight against cancer drug resistance
Dr. Gottesman, one of the keynote speakers at SLAS2016, is a true pioneer in the field of cancer drug resistance, helping us understand why seemingly successful chemotherapies often meet increasing resistance. To prepare for his keynote speech on Monday, January 25, 8:30 am PST, read about his brilliant work, which has deepened our understanding of how cancer drugs can be made to work better.
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Dan Eustace: Bridging the gap, escaping the silo and learning to listen
For Dan Eustace, who will be offering a workshop called “The Negotiation Process” at SLAS2016, the event is the highlight of his professional year. Dan has been going to the SLAS annual event and exhibition for the past five years and says, “It’s the best event I’ve ever been to." We spoke to Dan about his workshop, why he feels SLAS is so important and his perspective on the future for life sciences.
Dylan Nelson on reducing costs and simplifying workflows in a drug screening center
If you’re working in drug screening and development or characterizing small molecules and want to find out how to reduce costs and simplify workflows, don't miss Dylan Nelson’s presentation on how OTRADI did just that at 1:00 p.m. on Monday, January 25 at the Tecan booth 831.
Rick Thomas: automated glucurodinase removal from pain management samples
Precision Diagnostics has a lot to offer anyone wanting to increase efficiency and throughput of liquid samples. Rick Thomas, Chief Scientific Officer at Precision Diagnostics will be sharing his robotic sample processing experience at the Tecan booth on Monday, 25 January at 3:00 p.m.
Joe Zer and simplification with the Fluent approach
Joe is an Associate Scientist II at Dart NeuroScience, a company of visionaries, innovators and optimists. Anyone wanting to know how to really maximize the potential of Fluent should definitely check out Joe Zer’s presentation at 10:00 a.m. on Tuesday, January 26 at the Tecan booth 831.
Dr. Kristjan Plaetzer and automated metabolic analysis in photodynamic tumor therapy
Dr. Plaetzer's work focuses on applying the photodynamic approach against pathogenic microorganisms in human medicine and food. If you’re the head of an academic laboratory, interested in cancer therapies or long-term research on metabolic processes, don’t miss Dr. Kristjan Plaetzer’s presentation at 11:00 a.m. on Tuesday, January 26 at the Tecan booth.
Wolfgang Jörg on the path from testing to a successful project
Considering a new lab automation system or simply want to keep up to date with the latest in innovation? Put the date of Wolfgang Jörg’s presentation at 2:00 p.m. on Tuesday, January 26 at the Tecan booth 831 at SLAS 2016 in your diary.
Get the scoop on integration solutions from Vince Ahlheit
People may not be familiar with the extent of integrated solutions that Tecan offers. I see my role as helping you understand how we can meet your needs in a variety of applications, from mass spectrometry to sample preparation. I can also show you round some of our clever new stuff, like the integrated 3rd party robotic arm on the Freedom EVO platform and a new release of Fluent software with added functionality.
David Wold is ready to discuss your liquid handling challenges
For over a decade now I have helped our partners meet their challenges in liquid handling. So if there’s anything you need to do or know in that area then I should be able to help. And if I can’t, I know someone who can. I can help you choose the components you need for maximum reliability and performance. This ranges from specialised pumps, valves and software, to consumables like disposable tips for a range of products across a variety of platforms.
Talk to Avinash Peddi about custom automation integration projects
"You might well have questions around whether a particular lab process can be automated. If that’s the case I can help you look at all the available options. It’s likely that automation is possible, but I can help you understand to what degree. It could be the entire process, or just the key phases.”
Automate drug discovery assays with Tecan Expert Simon Fogarty at SLAS2016
“With over 30 years in the business, most of it involved in lab automation, I can help with any challenges around the automation of assays. There are many questions you may want to ask and I’d like to be able to shed new light on this area – perhaps helping you to consider ways of working with robotics you haven’t thought of. Whether you’re completely new to the area or want to expand your knowledge, I’d be happy to help.”
Kevin Moore speaks your language in drug discovery, compound management & ADME
“I have a deep understanding of the drug discovery world – and the benefits that automation can provide in that arena. In the past I have chaired the Compound Management Track at SLAS conferences. Over the years I have used a variety of equipment, so I am not just in the Tecan ‘bubble’. For anyone interested in the drug discovery world, I can talk the same language.”
“As a product manager I can help you whatever stage you are at. If you are just thinking about getting started with automation then I can go through different possibilities for how your company can use robotics to improve its workflows. If you’re already experienced in the field we can discuss specific challenges you have or the latest hot topics, like liquid level detection technologies or how to physically integrate a range of different devices.”
Gain from Mike Muller's genomic workflows expertise at SLAS2016
“I see my role as talking with you to understand what your lab wants to do in the field of NGS reagents, then matching your needs to our hardware. I can suggest different combinations of automation, for instance robots of different sizes or with different types of arms. I am also looking forward to talking with power users who have complex programming needs, or simply want to go bigger and faster. If you want to see scenarios where similar applications are already in use I can help with that too.”
“If you have any questions regarding automation of Next Generation Sequencing, then I can help. It can be seen as an intimidating subject but there’s no reason you shouldn’t feel confident that automation will make a massive difference. Tecan has extensive experience in automating genomic workflow. I can also talk you through the benefits you can expect, like maximising reproducibility and reducing human error.”
Discuss detection and cell biology with Michael Fejtl at SLAS2016
“There are so many new features available with our Spark multi-mode readers and I can help you see how they fit in with your workflow. You might want to know about cooling, for instance, and how we can automatically ensure a stable temperature. I can also help you with any challenges you have around cell based assays and explain how you can free up more time for research by automating the entire workflow – including cell counting for cell suspension and cell imaging in microplates.”
“If you have yet to experience the benefits of automation in your lab, then I can take you through the options. Our NGS platform can offer mid or high throughput options, giving you the ideal transition from manual tasks to automation. If you’re already using robotics in the lab then I can show how new developments can help you do things better and faster – adding greater value to a range of different application areas.”
Find out about self-aware automation from Tecan Expert Hal Wehrenberg
Hal Wehrenberg can answer your questions about lab automation and will present at the Tecan booth #831: "Self-aware automation" at 4:00 p.m. Monday, January 25. Hal has been at Tecan for the last eleven years and is a Software Product Manager on our Fluent platform.Read more ...