Tecan Journal

HMGB1 – a silent partner in cancer

Many people in the life science and medical communities will never have heard of HMGB1 or, to give it its full title, high mobility group box 1 protein. Despite this, it is the most common nuclear protein after the histones – with around a million copies per cell – and plays a key role in the body’s response to everything from trauma and infection to a stroke and heart attack.