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DR: ERIC P. BENNETT | INDEL detection, the “Achilles heel” of precise genome editing.

27.09.2022

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of gene editing applications in life sciences, and shows great promise for development of the next generation gene therapies. PN technologies share the common principle of inducing a DNA doublestrand break (DSB), followed by cellular repair of the induced DSB, resulting in the formation of insertions or deletions (InDels) at the user-specified genomic site. This presentation outlines how methods have been developed for detection of the essential PNinduced primary outcomes, and how recent advances enable turning of a complex pool of different InDel events into informative InDel profiles.