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DR: ERIC P. BENNETT | INDEL detection, the “Achilles heel” of precise genome editing.



of gene editing applications in life sciences, and shows great promise for development of the next generation gene therapies. PN technologies share the common principle of inducing a DNA doublestrand break (DSB), followed by cellular repair of the induced DSB, resulting in the formation of insertions or deletions (InDels) at the user-specified genomic site. This presentation outlines how methods have been developed for detection of the essential PNinduced primary outcomes, and how recent advances enable turning of a complex pool of different InDel events into informative InDel profiles.