Biopharmaceutical manufacture in miniature with Tecan

The Biomolecular Separation Engineering group at the Karlsruhe Institute of Technology, Germany, is using the Freedom EVO® liquid handling workstation, equipped with the Te-Chrom™ module and Atoll’s 96-array MediaScout® RoboColumn system, to create a fully automated chromatography platform for biopharmaceutical process development.

 

Professor Jürgen Hubbuch explained the team’s research strategy: “We are using automation to help us learn as much as possible about processes before synthesis and scale-up, aiming to significantly enhance process performance and reduce production costs. Tecan’s Freedom EVO workstations offer unrivalled flexibility for integration of new hardware components developed in-house, and a very high level of space on the deck of the instrument.”

 

“One of the main tasks performed on our Freedom EVO workstations is assessing chromatographic separations of new biopharmaceuticals using Atoll’s 96-array MediaScout RoboColumns. The combined Tecan / Atoll solution allows us to generate a large amount of data within a short time frame, and automation permits us, for the first time, to exploit Design of Experiment (DoE) strategies, combining short experimental time and low material consumption. This not only cuts the development time for process optimization significantly, but also gives a much better understanding of the process.”

 

To find out more on Tecan’s Freedom EVO platforms, visit www.tecan.com/proteinchromatography

 

MediaScout is a registered trademark of ATOLL GmbH

 

 

 

About Tecan

Tecan (www.tecan.com) is a leading global provider of laboratory instruments and solutions in biopharmaceuticals, forensics, and clinical diagnostics. The company specializes in the development, production and distribution of automation solutions for laboratories in the life sciences sector. With its subsidiary REMP (www.remp.com), Tecan is the market leader in automated laboratory storage and logistics systems. Its clients include pharmaceutical and biotechnology companies, university research departments and diagnostic laboratories. Founded in Switzerland in 1980, the company has manufacturing, research and development sites in both North America and Europe and maintains a sales and service network in 52 countries. In 2008, Tecan generated sales of CHF 396 million (USD 366.7 million; EUR 250.7 million). Registered shares of Tecan Group are traded on the SIX Swiss Exchange (TK: TECN/Reuters: TECZn.S/Swiss security number: 1210019).

 

 

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