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Bacterial endotoxin testing (BET) is an important quality control check for the pharmaceutical and biomedical industries, ensuring that injectable or intravenous drugs and implantable medical devices are safe to use. Lonza offers a wide range of reliable BET solutions for QC labs, including high throughput, automated systems for microplate-based endotoxin detection.
Metagenomics is rapidly emerging as a promising method for disease diagnosis, but the need for manual processing is delaying turnaround times and limiting clinical uptake. Dr John Rossen, Head of Global Research & Development and Product Strategy for Europe at IDbyDNA Inc, discusses how the company has developed a test that can give detailed diagnostic reports on pathogens associated with respiratory infections and urinary tract infections, and how automation will speed the transition of this assay from research to routine testing in clinics.
Tethis has automated its microFIND™ technology by adapting a Freedom EVO® liquid handling platform with accessories to accommodate the characteristics of this microfluidic device. The resulting system, known as autoFIND-F75, provides an affordable way of performing large scale FISH screening of cytological specimens.
One of the many functions of Bayer Schering Pharma’s Berlin research facility is to provide recombinant protein tools for the company’s lead discovery process. Scientists there have integrated two Freedom EVO® workstations into the protein production process, ranging from cloning and expression to purification, and including automation of GE Healthcare’s MultiTrap® 96-well plates.
French pharmaceutical company Galderma specialises in the development of drugs for a variety of dermatological complaints, including acne, rosacea and psoriasis, and has chosen a customized Freedom EVO® 200 liquid handling workstation to manage its huge library of compounds used in high throughput screening.
Scientists at Millipore have developed an automated method for the neural differentiation of embryonic stem cells (ESCs) in monolayers, instead of the non-automatable, three-dimensional cell clusters that are typically used.
In-gel digestion is a major bottleneck for large scale proteome analyses and is therefore a prime candidate for automation. The Proteomics Group at the Max Planck Institute (MPI), Göttingen, in collaboration with Tecan, has developed an innovative automated solution based on Tecan liquid handling workstations.
UK Biobank is using 11 Freedom EVO® liquid handling workstations to process thousands of samples each day in preparation for a long-term initiative aimed at improving the prevention, diagnosis and treatment of a wide range of serious and life-threatening illnesses, including cancer, heart diseases, diabetes, arthritis and forms of dementia.
At the Coriell Institute for Medical Research, the Coriell Cell Repositories serve the needs of the entire scientific research community by maintaining the world’s largest collection of human cell lines. Scientists there are using a Freedom EVO® 150 liquid handling workstation to prepare DNA from these cells, to distribute to research scientists investigating human disorders worldwide.
Based in Männedorf, Switzerland, Tecan Integration Group (TIG) Europe is a team of 20 highly experienced engineers and project managers, offering tailor-made automated solutions for biopharma, genomics, forensics and protein science laboratories. Uwe Heuzeroth, head of project management, tells us more about TIG Europe.
The Research Centre for Agriculture and Forestry Laimburg works closely with the farming industry in South Tyrol in a variety of agricultural research projects, from fruit and wine production to plant protection, vegetable cultivation, agricultural chemistry and fish farming.
In Yokohama, Japan, RIKEN (The Institute of Physical and Chemical Research) has just completed a structural genomics and proteomics project to determine numerous protein structures, for which the researchers chose Tecan’s liquid handling workstations to prepare the protein samples for NMR spectroscopy and X-ray crystallography.
Over the last decade, the Livestock Improvement Association of Japan (LIAJ) has developed a DNA and beef sample database capable of parentage discrimination analysis for pedigree registration and individual identification of every head of cattle in Japan. To handle the large number of samples involved, scientists at LIAJ have chosen Tecan’s Freedom EVO® 200 workstation, with barcoded sample identification, for the automated extraction of DNA.
Researchers at Genomic Health Inc., California, are using several Freedom EVO® 200 workstations and a Genesis platform to automate the development and routine screening of gene panels for predicting the risk of recurrence and response to treatment of breast cancer.