The COVID-19 pandemic has highlighted the importance of biosurveillance to understand, control and limit the spread of human diseases. In response to the pandemic, the laboratories at PTP Science Park in Lodi, Italy, quickly enhanced their set-up, introducing various assays to gain a deeper understanding of the virus. Researchers now not only diagnose COVID-19, but also measure anti-SARS-CoV-2 antibody levels after infection and vaccination to learn about the pathogenesis of the disease and how our immune systems respond to infection.