The COVID-19 pandemic has forced everyone to look at laboratory routines to see if they are really pandemic proof. For example, the explosive demand for high throughput genomic analysis often creates upstream pressures to process many more samples and prepare high quality DNA. The rapid shutdown of non-essential workplaces and services, coupled with the surge in demand for laboratory testing, put immense strain on multiple aspects of normal laboratory operations, such as strict rules on the need for personal protective equipment – which was in limited supply – and required physical distancing. Consumables stocks and reagents also dwindled, as they were being used at a much faster rate and supply chains were affected by global demand. Now that the limitations of current laboratory routines have been highlighted, it’s time to consider how to make laboratories pandemic proof.
SARS-CoV-2 has hit the world by storm and testing has had a major part to play in the fight against the virus, helping to track cases and slow rates of infection. ABC Labs, based at the Karolinska campus in Stockholm, was founded soon after the start of the pandemic with the specific purpose of establishing large scale and high quality PCR and ELISA COVID-19 testing in Sweden. The laboratory analyzes thousands of tests on a daily basis in partnership with the country’s Public Health Agency and a number of regional and private healthcare providers, to help stop the virus.
UK Biocentre has been central to the UK Government’s response to the COVID-19 pandemic, repurposing its entire facility to become a national center for SARS-CoV-2 molecular testing. To help meet an ambitious target of 100,000 tests per day across the country, the organization has established a new mega-lab, partnering with Tecan to design and commission a suite of liquid handling automation platforms in just a few weeks.
The emergence and outbreak of the novel coronavirus SARS-CoV-2 at the end of 2019 has created an urgent need for testing to help limit the spread of COVID-19. AusDiagnostics has used its patented, multiplexed-tandem PCR technology to develop a test to detect SARS-CoV-2 and distinguish between the different causes of coronavirus-like infections.
The COVID-19 pandemic has required an unprecedented level of collaboration within the scientific community, as labs around the world aim to characterize and understand the SARS-CoV-2 virus in order to develop and implement new diagnostic tests, therapeutics and vaccines. This cooperative approach has led to some unexpected partnerships, as techniques and knowhow from across numerous disciplines are brought together to accelerate research and testing activities. Professor Nir Friedman’s team at the Hebrew University of Jerusalem has been at the center of one such situation, using its knowledge of workflow automation from investigating yeast genomics to develop a novel large-scale sequencing-based assay for the detection of SARS-CoV-2.
The COVID-19 pandemic sweeping the globe has highlighted the need for the rapid development of new diagnostic tests, therapeutics and vaccines in response to emerging infectious diseases. Advanced gene assembly techniques represent a powerful tool to aid these efforts, and are currently allowing the construction of synthetic SARS-CoV-2 genomes for research and development activities. Codex DNA is at the forefront of this approach, using its knowhow and BioXp™ 3200 system to supply labs across the globe with the gene constructs required to accelerate the design and optimization of vaccines and treatments.
The ever-increasing throughput and ever-decreasing cost of next generation sequencing have made this technology a practical and affordable solution for everything from molecular diagnostics and antimicrobial susceptibility testing to crop research and environmental monitoring. For many of these applications, the bottleneck in the workflow – which can account for considerable hidden costs – lies in sample extraction. Tecan has partnered with Zymo Research to offer labs an automated and optimized solution for nucleic acid processing.