Work to characterize and further understand the molecular pathology of SARSCoV- 2 became a focus for many virology departments following the identification of the novel virus responsible for COVID-19. Drs Marek Widera, Alexander Wilhelm and colleagues at University Hospital Frankfurt, Germany, turned their attention to developing an in vitro cell culture model that could realistically mimic the viral replication cycle, to decipher the mechanism of COVID-19 infection.