The initial screening of chromatographic conditions can be a major bottleneck in the development of protein purification protocols. Italian company BiCT – Biological and Chemical Technologies – has turned to automation to overcome this issue, implementing parallel processing of miniature chromatography columns on a liquid handling platform to enable rapid simultaneous screening of a range of conditions. This maximizes the prospect of achieving the best result for each project while saving time and resources.
High throughput bioprocess development is essential for optimizing run parameters prior to scale-up. University College London’s Advanced Centre for Biochemical Engineering is harnessing the possibilities afforded by automation, using custom-built scripts and programs to make its liquid handling platforms accessible to inexperienced users.