The prevalence of eye diseases is rising around the world and, for most of them, there are no effective therapies available. Disorders that impair vision – such as macular degeneration or glaucoma – are a leading cause of disability and loss of an independent lifestyle in aging populations. At the other end of the spectrum, myopia – or short-sightedness – is also on a steep incline, with up to 90 percent of teenagers being affected in some regions. Researchers in Basel are using various cutting-edge tools – including single-cell genomics – to understand the molecular mechanisms behind some of these diseases, with the aim of developing effective therapeutics.
Mitosis plays an essential role in growth and cellular replacement, and is often dysregulated in cancers, making the process of therapeutic interest. Researchers at the University of North Carolina at Chapel Hill (UNC Chapel Hill) are developing novel cell imaging tools to help them classify key components of mitosis and identify new therapeutic targets.