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Several outbreaks of the Zika virus have been reported around the world since its discovery in 1947, but a commercially available treatment for the disease is still not available, and scientists continue to search for the best antiviral agent....
Opioid addiction, alongside addiction to other substances, is a significant public health, social and economic challenge in the US. In 2017, the opioid epidemic was declared a public health emergency by the Department of Health and Human Services,...
Mitosis plays an essential role in growth and cellular replacement, and is often dysregulated in cancers, making the process of therapeutic interest. Researchers at the University of North Carolina at Chapel Hill (UNC Chapel Hill) are developing...
The race has been on since the start of the pandemic to develop vaccines and drugs to fight against the SARS-CoV-2 virus. Vaccine development has proven successful, with vaccine roll-out underway in many countries, but the need remains to identify...
Carbonic anhydrases (CAs) catalyze the reaction between water and carbon dioxide to regulate pH and fluid balance in vivo. Deviations in CA activity have been shown to correlate with bone, lung and liver diseases, as well as obesity, type II...
Laboratory automation is increasingly common in life sciences research, helping to tackle some of the challenges that come with manual workflows, including inefficient operation, limited throughput and challenges of reproducibility. However, most...
3D cell culture is an area of great interest in the drug development industry, as 3D models give a more accurate representation of how cells act in response to compounds in vivo. Merck’s Cellular Pharmacology Department specializes in the use of...
Recent viral outbreaks have alerted the world to the serious consequences of viral disease, yet the development of new antiviral drugs is challenging because of problems such as resistance or lack of molecular targets. Researchers at Zhejiang...
Damage to the brain or spinal cord can be life changing for affected individuals, and it was historically thought that these injuries would not heal and could not be repaired. However, since the discovery of neurite growth inhibitors by Professor...
Drug discovery is a lengthy and expensive process, particularly in the early candidate identification stages, where screening of large numbers of compounds is required. Researchers at the University of Central Florida are using artificial...
The VirPath laboratory is focused on the study of influenza and other respiratory viruses to identify new antiviral molecules and develop innovative vaccines. Digital dispensing and luminescence-based assays play an important role in the evaluation...
Detecting adverse off-target effects is crucial to ensure the safety of potential therapeutics, but limited throughput and ethical considerations have traditionally forced pharmaceutical companies to perform safety pharmacology studies at a late...
Small molecule drug discovery involves a range of functional assays that have traditionally relied on manual cell counting techniques to monitor proliferation, migration and invasion. Automated cell counting is enabling the EB House Austria to save...
The successful treatment of inflammatory diseases may lie with controlling the production of particular proteins, driving efforts to identify translational repressors for drug targeting. Scientists at the Moulder Center for Drug Discovery Research...
Developing therapies to treat rare diseases is often hindered by the limited availability of primary patient samples. Without these precious samples, it is difficult to understand the fundamental biology of these conditions or screen compound...
The HP D300 Digital Dispenser is enabling researchers at the Columbia Genome Center’s High-Throughput Screening Facility to quickly and simply create dose-response curves for combinations of up to nine compounds, allowing rapid generation of EC 50...
Automation brings more than simply speed to the laboratory. Modern software is taking the headache out of serial dilution and normalization calculations, supporting assay development and delivering reliable results for international healthcare...
Chinese medicine combines herbal remedies with acupuncture, massage, exercise and diet to provide alternative therapies for a wide range of conditions. Despite drawing on over 2,500 years of traditional knowledge, little is known about the mode of...
Biomolecular interaction analysis plays an important role in the pharmaceutical industry. SensiQ Technologies has optimized surface plasmon resonance technology for drug discovery applications, developing an automated system that can provide rapid...
Dart NeuroScience specializes in the development of novel therapeutics targeting neurological disorders, with an emphasis on impairment of cognitive functions such as memory.