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Tecan Journal

Selected category: Spark

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Transforming Drug Classification: Tecan’s Spark in the Fight Against Synthetic Cannabinoids

The proliferation of new psychoactive substances (NPS), including synthetic cannabinoids, is challenging regulatory systems and public health worldwide. Unlike conventional drugs, NPS often lack established safety profiles and pose unpredictable...

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Targeted Protein Degradation: multiplexing PROTACs and molecular glues screening

Targeted protein degradation (TPD) is growing to be one of the most promising therapeutic approaches to targeting previously undruggable proteins involved in many different diseases. For this purpose, different classes of molecules are being...

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Don’t miss a beat with live cell imaging

US-based company zPREDICTA™ has created a novel 3D technology that reconstructs physiologically-relevant and organ-specific human microenvironments for drug discovery and development. High throughput cell imaging and real-time cytometry of these 3D...

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Fluorescence imaging shines a light on systems biology

Chromosomal tagging using advanced fluorescent labeling techniques can help us to understand cells at a systemic level. Researchers in Germany have developed a universal approach for CRISPR-Cas12a-assisted PCR tagging of mammalian genes, using...

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Digital connectivity for Lab 4.0

In a post-pandemic world, the need for real-time and remote connectivity is more crucial than ever. Today’s laboratory equipment and analyzers are capable of generating more data than ever before, creating new challenges for data processing and...

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Empowering CORE oncology research

Christophe Deben and the team at the University of Antwerp’s Center for Oncological Research (CORE) were the lucky recipients of a fully loaded Tecan Spark® Cyto plate reader with live cell imaging and real-time cytometry, after winning a Tecan...

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Live cell imaging: how to gain more control

Live cell imaging is one of the most important techniques in life sciences today. But behind every great imaging assay, pity the poor scientist grappling with the demands of biological variability and complex kinetic assays. Live cell experiments...

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Spark® Cyto to empower CORE oncology research

Congratulations to Christophe Deben and the team at the University of Antwerp’s Center for Oncological Research (CORE) on winning a fully-loaded Spark Cyto plate reader with live cell imaging and real-time cytometry!

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A Spark® of hope for nerve damage repair

Damage to the brain or spinal cord can be life changing for affected individuals, and it was historically thought that these injuries would not heal and could not be repaired. However, since the discovery of neurite growth inhibitors by Professor...

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Developing novel influenza inhibitors

The VirPath laboratory is focused on the study of influenza and other respiratory viruses to identify new antiviral molecules and develop innovative vaccines. Digital dispensing and luminescence-based assays play an important role in the evaluation...

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From tennis elbow to heart failure – regenerative medicine for life

Regenerative medicine aims to stimulate the body’s own repair mechanisms to heal damage to tissues or organs. A wide range of biological materials – from extracellular matrix components and platelet lysates to stem cells – can be used to induce...

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Designer chemotherapy

Brain tumors are the most common cause of mortality in childhood cancer patients, and treatment options are limited, especially for recurrent cases. Researchers at the University Hospital Düsseldorf are using automation to develop a more...

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Cell counting made easy

Small molecule drug discovery involves a range of functional assays that have traditionally relied on manual cell counting techniques to monitor proliferation, migration and invasion. Automated cell counting is enabling the EB House Austria to save...

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Biosensors light the way for drug development

The successful treatment of inflammatory diseases may lie with controlling the production of particular proteins, driving efforts to identify translational repressors for drug targeting. Scientists at the Moulder Center for Drug Discovery Research...

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Detection at the molecular level

Many common food additives and pharmaceuticals make their way directly into aquatic ecosystems. While their effects on humans are well documented, the impact on the environment and marine lifeforms is largely unknown. This has become the focus of a...

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More than skin deep

LMSM studies the effects of changing environmental parameters on the physiology of bacteria, and has recently began using this expertise to help the cosmetics industry. Many of these investigations involve absorbance-, luminescence- and...

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Targeting the treatment of solid tumors

Tessa Therapeutics has developed a virus-specific T cell therapy for the treatment of solid tumors, which has shown promising results in early trials. Stringent quality control, including time-resolved fluorescence cytotoxicity assays performed on a...

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Accelerating R&D through collaboration and automation

Discovering and developing new antimicrobial drugs to tackle antibiotic resistance requires an understanding of how bacteria respond and adapt to new compounds. A range of tests are needed to determine the efficacy of potential drugs, such as...

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Luciferase comes to the devil’s rescue

Wild Tasmanian devils are vulnerable to a facial cancer discovered in 1996 and identified as a transmissible tumor a decade later. The contagious disease originated in northeastern Tasmania and spread throughout the country, decimating the devil...

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Designed for flexibility, built for speed

Multidisciplinary research calls for multifunctional laboratory equipment capable of rapidly switching between applications. Staff in the Department of Biomedical Engineering at the TU Eindhoven understand that having the right instruments for your...

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Vectoring in on success

Genetic modification of mammalian cells is now a routine daily activity in academic and industrial R&D laboratories around the world, with viral vectors – such as lentivirus – commonly used to create new cellular models for a wide range of...

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