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By Oliver Schmidt
HMGB1 is a key mediator in the immune response to SARS-CoV-2, and increased levels can be an important indicator for COVID-19 understanding and its prognosis. In this final piece in our series, we look at the performance of Tecan’s...
By Oliver Schmidt
In the first article in this series, we looked at how HMGB1 has taken an increasingly important position as a key mediator in the immune response, playing a major role in many diseases, from cancer to coronavirus. There is now...
By Siegfried Sasshofer
Photodynamic Therapy (PDT) is being increasingly recognized as having potential for the treatment of tumors, especially dermatological. But using conventional manual methods of recording the metabolic processes that occur as a...
By Oliver Schmidt
HMGB1 is a key mediator in the immune response and increased levels can be important indicators of disease. In this, the last in our series on HMGB1, we will look at the performance of the IBL HMGB1 ELISA Kit, which has been used...
By Oliver Schmidt
In the first article in this series, we looked at how HMGB1 has taken an increasingly important position as a key mediator in the immune response and as such plays a major role in a large number of diseases – from sepsis to cancer....
By Oliver Schmidt
As a nuclear protein present in most cell types, HMGB1 (high mobility group box 1) is a key mediator of the immune system in health and disease. Interest in HMGB1 has increased dramatically as the protein has been shown to be...
By Nicholas Smith
We may well be on the threshold of a new hope for oncology. Shorthanded to ctDNA, circulating cell free tumor DNA is sloughed off from tumors. It can be detected in liquid biopsies of just a few milliliters of blood. This could...
By Kevin Moore
How can we improve upon the completely artificial situation that we have today for screening drugs? We spoke to Dr. Christopher Millan, Co-Founder and CTO of the up-and-coming company, CellSpring. Based in Zürich, Christopher Millan...
By Achim von Leoprechting
Next-generation sequencing (NGS) is poised to become a decisive tool in diagnostic, therapeutic, and prognostic applications in oncology. In the first part of this two-part series, we saw that sequencing tumor-derived DNA...
By Achim von Leoprechting
Massively parallel sequencing has rapidly become a must-have tool of the trade in molecular biology and drug discovery research. In recent years, the cost of next-generation sequencing (NGS) has declined exponentially,...
By Martin Braendle
(Part 2 of 2. Read Part I). In 1948, Bill Koster of the Variety Club of New England and Dr. Sidney Farber working at the Children’s Hospital Boston had launched The Children's Cancer Research Fund, aimed at supporting a hospital...
In his book, The Emperor of All Maladies, Siddhartha Mukherjee tells the story of one of the turning points in the history of cancer medicine. A turning point that he dates to May 1947. In this two-part article we will look at how...
By Simon Fogarty
(Part 3 of 3: Read Part 2) In the first part of this series, we introduced you to imatinib (Gleevec). This drug was originally launched in 2001 as a potent treatment for chronic myeloid leukemia (CML). It also proved to be effective...
By Simon Fogarty
(Part 2 of 3: Read part 1) 'The so-called ‘War against Cancer’ started with US President Richard Nixon’s National Cancer Act of 1971. It turned out to be many battles on many fronts as cancer was confirmed to be not one but a...
By Simon Fogarty
In 1996, Dr. Charles Sawyers at Memorial Sloan Kettering Cancer Center, USA, became involved in the initial testing of a drug for the treatment of chronic myeloid leukemia (CML). The drug, imatinib (later to be launched as Gleevec),...